The effect of fertilization with Tithonia diversifolia on the productivity of zooplankton and the growth performance of fingerlings of Oreochromis niloticus were investigated between May and October 2014 at the IRAD of Foumban in order to contribute to the improvement of the production of the fishes. A total of 513 fingerlings with an average weight of 8.89 ± 0.91 g, were randomly distributed into six ponds of 85 m² previously equipped with compost crib occupying 5% of the surface area. Each randomly selected pond was administered weekly doses (3,75kg; 5kg and 6, 25 kg/are) of T. diversifolia previously chopped. At the end of the study, the highest biomass of zooplankton were obtained with the highest dose (6,25kg/are). But the growth performances of O. niloticus and its productivity were significantly higher with the dose of 5kg/are. The dose of 5kg/are of Tithonia proved most convincing to improve the production of Oreochromis niloticus.