A total of 286 marine fishes of “Dicentrarchus labrax, Dicentrarchus punctatus and Sparus aurata” were collected from Suez Canal in Ismailia Province, Egypt. Abundant mixed parasitic infestation implicating Cymothoid isopods, Lernanthropus, Caligus, Praniza larvae of Gnathiids, Monogeneans and Digeneans was frequently seen. There were double and tripartite parasitism and a quaternary parasitism especially by crustaceans. The total prevalence of mixed parasitic infestation was 23.42% among examined fishes, and D. labrax is a prospect host for mixed parasitic infestations (56.52%). The histopathological picture was recorded as a completed detachment or degeneration of primary gill lamellae, severe congestion and hyperplasia. Results of this study provided the parasites involved in mixed infestation and their effect on the fish health.